Description
CLEC4C (C-type lectin domain family 4 member C), also known as BDCA2, CLECSF11, CLECSF7, DLEC and CD303.
Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cell.
Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man.
Binds to serum IgG.
Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells.
May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells.
May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium